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AboutPricing
Drug ReportsLeucovorin calcium
Leucovorin calcium
Leucovorin (leucovorin calcium) is a small molecule pharmaceutical. Leucovorin calcium was first approved as Leucovorin calcium on 1982-01-01. It is used to treat folic acid deficiency and megaloblastic anemia in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
hemic and lymphatic diseasesD006425
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name
Status
Last Update
enbrace hrunapproved drug other2025-01-02
enlyteunapproved drug other2022-07-01
leucovorinANDA2014-09-26
leucovorin calciumANDA2025-05-06
paxlyteunapproved drug other2024-12-19
Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
V: Various drug classes in atc
— V03: All other therapeutic products
— V03A: All other therapeutic products
— V03AF: Detoxifying agents for antineoplastic treatment
— V03AF03: Calcium folinate
HCPCS
Code
Description
J0640
Injection, leucovorin calcium, per 50 mg
Clinical
Clinical Trials
4992 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938—C95——1——1
Promyelocytic leukemia acuteD015473—C92.4——1——1
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLeucovorin calcium
INNcalcium folinate
Description
Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to treat folate deficiency that results in anemia, and methanol poisoning. It is taken by mouth, injection into a muscle, or injection into a vein.
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
Nc1nc(=O)c2c([nH]1)NCC(CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])cc1)N2C=O.[Ca+2]
Identifiers
PDB—
CAS-ID1492-18-8
RxCUI—
ChEMBL IDCHEMBL1201138
ChEBI ID—
PubChem CID6006
DrugBankDB00650
UNII IDRPR1R4C0P4 (ChemIDplus, GSRS)
Target
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Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 15,903 documents
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Safety
Black-box Warning
Black-box warning for: Enlyte
Adverse Events
Top Adverse Reactions
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43,678 adverse events reported
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